Jacksonville Jaguars (0-3) at San Diego Chargers (2-1)

Sunday, 4:05 p.m. ET, at Qualcomm Stadium, San Diego — TV: CBS

*TV announcers: Andrew Catalon, Steve Tasker

*Keys to the game: Missed tackles are becoming an epidemic for the Jaguars, who had 31 in the past two games. More of the same could cripple the Jaguars against a ball-hogging offense like the Chargers.

In Blake Bortles’ first NFL regular-season start, the Jaguars will simplify the game plan. Bortles will be allowed to make the downfield throws but he won’t be asked to do too much and try to win the game by himself. The Jaguars desperately want to get some kind of running game going. Look for Denard Robinson to get double-digit carries in this game after turning in a solid performance against the Colts. Toby Gerhart is still trying to show he was worth the millions that the Jaguars paid for him in the offseason, even though he had never started an NFL game.

QB Philip Rivers brings veteran calm to the San Diego huddle even without his top two backs available. Donald Brown (31 touches last week) is likely in line for another heavy workload.

*Matchup to watch — Chargers TE Antonio Gates vs. Jaguars secondary: The Jaguars allowed three tight ends for Indianapolis to combine for 11 catches, 102 yards and two scores last week and in Jacksonville’s last 17 regular-season games, opposing tight ends have caught 110 passes for 1,257 yards and 13 scores. Gates is back playing at a peak level and will see extra attention from the Jaguars.

*Player spotlight — Chargers ILB Kavell Conner: He’ll slide into the starting role vacated by Manti Te’o (foot), who is likely to miss several weeks. Conner will be tested by a Jacksonville offense that wants to establish the run.

*Fast facts: Gates has 29 catches in five career games against the Jaguars. … Rivers can set a franchise record with a touchdown pass in 22 consecutive games Sunday.

WHO WILL WIN AND WHY

The Jaguars allow 466 yards per game and while Blake Bortles might bring a ray of hope, Jacksonville is no match for the San Diego offense.

*Our pick: Chargers 27-13