New York Giants (3-9) at Tennessee Titans (2-10)

Sunday, 1:00 p.m. ET, at LP Field, Nashville – TV: FOX

*TV announcers: Thom Brennaman, David Diehl, Laura Okmin

*Keys to the game: The Giants placed five more players on injured reserve this week, including two on each line, which only complicates their issues in the trenches. They have managed to hold the halftime lead in three of their past four games, but have struggled to put together four solid quarters of football.

Key is the status of RB Rashad Jennings, who missed practice midweek due to an ankle injury. If he’s not available, the Giants lack a true backfield threat to exploit the league’s worst run defense. The Titans were also torched for six touchdown passes by Texans journeyman QB Ryan Fitzpatrick last week, so Tennessee’s defense can be exposed through the air as well if QB Eli Manning can avoid turnovers.

The Titans are the only defense ranked lower than the Giants against the run, but Tennessee often abandons the run too quickly. With a banged up offensive line and rookie QB Zach Mettenberger trying to play through a shoulder injury, expect RB Bishop Sankey to be more of a focal point for as long as the Titans keep the game close.

*Matchup to watch – Giants WR Odell Beckham Jr. vs. Titans CB Blidi Wreh-Wilson: Wreh-Wilson was on coverage for much of last week against Texans WR DeAndre Hopkins, who caught nine passes for 238 yards and two touchdowns.

*Player spotlight – DE Damontre Moore: The second-year player is expected to start with Robert Ayers and Matthias Kiwanuka on injured reserve. The 6-5, 250-pound second-year player has primarily played on third downs, but will get an opportunity to show over the final four games that he can be an every-down contributor.

*Fast facts: The Giants have an NFL-high 20 players on season-ending injured reserve. … The Titans have allowed a league-high 338 points.

WHO WILL WIN AND WHY

The silver lining is one of the two longest losing streaks in the NFL will come to an end. Edge goes to the Giants with the Titans allowing six TD passes last week to complement their league-worst run defense.

*Our pick: Giants 27-20