Cleveland Browns (7-4) at Buffalo Bills (6-5)

Sunday, 1:00 p.m. ET, at Ralph Wilson Stadium, Orchard Park, N.Y. – TV: CBS

*TV announcers: Greg Gumbel, Trent Green, Evan Washburn

*Keys to the game: Browns head coach Mike Pettine is familiar with much of the personnel he will face Sunday, having served as the Bills’ defensive coordinator last season. While that may not have a direct impact on Sunday’s gameplan, Pettine knows the Browns must contend with the league’s No. 4-rated defense.

Buffalo’s defensive strength begins with the line, and it will be critical for RBs Terrance West and Isaiah Crowell to have early success. QB Brian Hoyer threw three interceptions last week and while the Bills’ secondary lacks dynamic playmakers, Hoyer will face a very good pass rush that will pressure him to make quick decisions. He’ll also have another week of practice with WR Josh Gordon, who poses a difficult matchup for Buffalo downfield if Hoyer has the time to stretch the field.

The Bills are certainly familiar with Pettine’s defensive philosophy, but Cleveland doesn’t enjoy the same personnel up front. The Browns are allowing 134.9 rushing yards per game and Buffalo will pound away with RBs Boobie Dixon, Fred Jackson and Bryce Brown in an attempt to control the field and the clock. QB Kyle Orton rarely pushes the ball further than 10 yards downfield, so it’s critical for the Browns to take him out of his comfort zone.

*Matchup to watch – Browns CB Buster Skrine vs. Bills WR Robert Woods: With teams beginning to shadow electric rookie Sammy Watkins, who will likely duel Joe Haden most of the day, the Bills need Woods to step up. He was targeted 11 times last week, coming up with nine catches for 118 yards and a touchdown.

*Player spotlight – Browns S Donte Whitner: Buffalo’s first-round pick in 2006 drew the ire of some current Bills this week with some comments he made over Twitter, including “Can you say Toronto Bills?!?!?!?!” in reference to the team’s unsettled ownership and long-term stadium situations.

*Fast facts: Crowell, who went undrafted, leads all NFL rookies with seven rushing TDs. … Dixon is the first Bill to block two punts in the same season since Steve Tasker in 1990.

WHO WILL WIN AND WHY

The quiet intensity in the Rust Belt rivalry has taken on an extra edge this week, and Buffalo returns home after its Monday night detour in Detroit to make yet another statement with a defense that can stop the run and create more QB unrest in Cleveland.

*Our pick: Bills 19-16