The New England Patriots defeated the Pittsburgh Steelers 28-21 in the NFL’s season opener on Thursday night. Tom Brady put on a clinic, as he completed 25-of-32 passes, for 288 yards and four touchdowns.

It was great to see two storied franchises go at it, but what’s even better is knowing that there are 15 more games to be played in the coming days. With that being said, let’s take a look at the can’t miss matchups in Week One.

Indianapolis Colts at Buffalo Bills

Before Rex Ryan came into the picture, the strength of the Buffalo Bills was their defense, which ranked fourth in the league a season ago. So you could only imagine how much more dangerous it’ll be with Ryan calling the shots.

One thing is for sure, Buffalo’s defense will get tested this Sunday against Andrew Luck and the Colts vaunted offensive attack. However, if you ask safety Aaron Williams, he’ll tell you Luck isn’t anything special.

“Just another NFL quarterback to me,” Williams claimed. “He’s really good at what he does. He manages the game really well, but, I mean, you know, we’ve faced quarterbacks like this before.”

Although Williams’ comments are going to add fuel to the fire, it’s not like he’s lying about the quality of quarterbacks Buffalo has faced. They play Tom Brady twice a year and last year they dueled against the likes of Peyton Manning, Philip Rivers and Aaron Rodgers.

Tyrod Taylor will be starting for Buffalo and apparently he’s a tough guy to game plan for.

“He’s a pain in the rear,” Colts head coach Chuck Pagano said. “It’s going to be a 60-minute battle for our guys. Let alone stopping the run, keeping the ball in front of us. Not allowing big plays and containing him.”

Indy is expected by many to compete for a Super Bowl title this year, while Buffalo has the potential to be special, but the jury is still out on Taylor as a starting quarterback.

Seattle Seahawks at St. Louis Rams

Anytime two division foes meet up, you can anticipate a hard-fought, physical matchup. If you know anything about the recent history between the Seahawks and Rams, you’ll realize that St. Louis always gives Seattle a tough time. With that in mind, there’s something different about this upcoming matchup.

Pro Bowl safety Kam Chancellor won’t be on the field.

“He’s not here and he’s not playing,” Pete Carroll said at practice Wednesday.

In order for St. Louis to pull off the upset, Nick Foles will have to take advantage of Chancellor’s absence. However, Chancellor’s replacement Dion Bailey claims to be prepared.

“I hope they plan to come at me,” Bailey said. “It’ll make my coming out party a lot more exciting. The more opportunities to make plays, the more plays I’ll make.”

Seattle’s biggest concern comes on the other side of the ball, in particular, the offensive line.

St. Louis possesses one of the top pass rushes in the league, which could become a major issue for the Seahawks.

New Orleans Saints at Arizona Cardinals

Over the past couple of years, these are two franchises that have been going in two different directions. New Orleans hasn’t won a playoff game since they won their lone Super Bowl back in 2009, while the Cardinals have been on the rise, hoisting a 21-11 record the last two seasons.

Heading into the new campaign, people are wondering if the Saints can revive their winning aura and if the Cardinals have what it takes to reach the next level.

Arizona was able to make the playoffs last year without Carson Palmer for majority of the season. With Palmer back under center, head coach Bruce Arians knows it’s now or never.

“We all know the clock’s ticking,” Arians admitted. “It is for a lot of guys on this team. You get a window to make a run and most of it depends on your quarterback, and right now, it’s our window to make our run with him.”

Against a fragile Saints defense, Arizona should be able to put up points.  If New Orleans is going to steal one in the Valley of the Sun, Drew Brees will have to perform at a high level against Patrick Peterson and company.

Detroit Lions at San Diego Chargers

These are two teams who wouldn’t surprise anyone if they went deep in the postseason or missed the playoffs entirely.

San Diego’s offensive line has been shaky over the years, but luckily for them, Detroit doesn’t have Ndamukong Suh or Nick Fairley anymore. In the same breath, Detroit does have a good secondary, but if they’re unable to get pressure on Philip Rivers, he’ll pick them apart.

The Chargers defense has a lot of question marks as well.

Just like every Sunday, Calvin Johnson will receive a lot of attention, which should allow Golden Tate to see tons of one-on-one coverage. The main question for Detroit offensively is if they’ll be able to establish a ground attack.

Joique Bell is listed as the starter , but rookie Ameer Abdullah is making a lot of noise.

There will be a plethora of talent on the field in San Diego this Sunday. The team that eliminates the self inflicting mistakes more will end up taking this one.

Baltimore Ravens at Denver Broncos 

Recent AFC history will tell you Baltimore and Denver are teams who are never to be overlooked, but this off-seasson you didn’t hear much about either.

In Baltimore’s case, they just don’t have the high profile names that generate buzz. It still doesn’t feel right seeing them without Ray Lewis, Ed Reed and now Haloti Ngata. At the same time, Baltimore has the pieces to not only make the playoffs, but they could make some major noise if they click at the right time.

Denver on the other hand is still a bonafide contender in the AFC, but it feels like people are just tired of hyping them up every season just to see them fall short in postseason play.

When it comes to this Week One showdown, the most intriguing matchup is the going to be Joe Flacco and his wide receivers going up against Denver’s vaunted secondary.

Outside of Steve Smith Sr., Baltimore’s receiving corps is unproven and that’s not a good sign when you’re set to go up against Aqib Talib and Chris Harris Jr.

Tennessee Titans at Tampa Bay Buccaneers

The NFL totally nailed this one.

Jameis Winston and Marcus Mariota will have their NFL debuts against each other. Due to their collegiate dominance and being selected 1-2 in the draft, the two will be linked together for the duration of their professional careers.

Last year, Mariota’s Oregon Ducks demolished Winston and Florida State 59-20 in the semifinal of the College Football Playoffs.

Although that game now is rendered meaningless, that performance months ago has to give Mariota some type of confidence heading into this highly anticipated contest.

Amidst all of the hype, Winston had an interesting way to explain how him and Mariota are.

“It’s like two horses at a racetrack,” he said. “When the alpha sees another alpha they just — (horse noise) — and they go on about their business.”

True football fans will have interest in all 15 games, but these six games are the ones you really want to circle on your calendar.