METAIRE, La. — There are two things that don’t happen too often in the Mercedes-Benz Superdome: the New Orleans Saints losing a game and quarterback Drew Brees being booed by the home crowd.

The Saints (4-5) experienced both on Sunday afternoon in a 27-24 overtime setback to the San Francisco 49ers (5-4) and kept them from padding their lead in the NFC South and climbing above the .500 mark for the first time this season.

They lost at home for the first time since the 2012 season finale, snapping their franchise-record 11-game winning streak in the building, and Brees, who has been the face of the franchise since coming to New Orleans in 2006, heard boos as he left the field at halftime on the short end of a 21-10 score.

Perhaps not all of the boos were directed at Brees, but he took a large share of the blame for the loss after throwing a pair of interceptions and losing a fumble in overtime that led to the game-winning field goal.

The first interception led to a touchdown and the other ended a promising Saints drive just before halftime when Brees, who’s now served up 10 picks this season, tried to force a throw at the goal line to Jimmy Graham with three defenders around him.

No one had to point out to Brees that the three miscues led to 10 points for the Niners and cost his team at least three points — which turned out to be big in a three-point loss.

“I probably deserved it … I would have booed myself,” said Brees, who has 18 touchdown passes and 11 total giveaways in nine games. “Something’s got to get fixed. I’m not happy about it. I can’t turn the ball over at the rate I’m turning it over. I’m aware of that.”

NOTES: RB Pierre Thomas, who has shoulder and rib injuries, missed his third consecutive game Sunday and it is unclear if he will be available for the Cincinnati Bengals Sunday. … ILB David Hawthorne (hand) didn’t play against the 49ers because of a hand injury for the second game in a row and his return is not known. … RB Khiry Robinson (forearm) missed a third consecutive game; it’s not known when he’ll return. … C Jonathan Goodwin, who missed the previous game with knee and ankle injuries, started on Sunday against the 49ers. … ILB Ramon Humber started his second straight game in place of David Hawthorne.

REPORT CARD VS. 49ERS

–PASSING OFFENSE: D — It doesn’t happen often, but the Saints had trouble throwing the ball at times against one of the NFL’s best pass defenses in their loss to the 49ers. Drew Brees completed 28 of 47 pass attempts for 292 yards with TDs of 11 and 2 yards to Jimmy Graham and a 31-yard scoring strike to Brandin Cooks. But the bad far outweighed the good as Brees threw a pair of interceptions, lost a fumble and was sacked twice to finish with a passer rating of 81.2. The first interception on the game’s third play led to a touchdown and the fumble in overtime set up the game-winning field goal. While he was only sacked twice, Brees faced constant pressure all day and had to throw the ball away several times to avoid sacks — which upset the rhythm of the passing game. Graham caught 10 passes for only 76 yards with a long of 15, while Cooks, who also had a 40-yard reception, finished with five catches for 90 yards while no other receiver had more than 36 yards.

–RUSHING OFFENSE: B — With the passing game struggling, the Saints had another good day running the ball. They had 136 yards and a 4.4 average on 31 carries with Mark Ingram doing the most damage. Ingram produced his third consecutive 100-yard game with 120 yards on 27 attempts with a long gain of 11 yards. Ingram, who is nursing a sprained right shoulder, again had to carry the load because of the absence of Pierre Thomas and Khiry Robinson. Both players missed a third consecutive game. Travaris Cadet had nine yards on two carries in relief of Ingram.

–PASS DEFENSE: C — The Saints, who lost cornerback Keenan Lewis to a knee injury twice during the game, had a solid day with one big exception. A 51-yard pass from Colin Kaepernick to Michael Crabtree on fourth-and-10 with 1:05 remaining in regulation may have saved the 49ers’ season. Flushed from the pocket by several defenders to the right sideline, Kaepernick stopped and threw the ball deep downfield and toward the center of the field where a wide-open Crabtree was running. Three plays later, the 49ers kicked a 45-yard field goal to send the game to overtime. Kaepernick didn’t have the best day with only 14 completions in 32 attempts for 210 yards and was sacked four times. He had a passer rating of only 76.3 but did have a 15-yard scoring pass to Anquan Boldin, who caught six balls for 95 yards. Held in check for much of the day, Crabtree added three receptions for 62 yards.

–RUSH DEFENSE: C — Despite doing a decent job on Frank Gore, the Saints wound up allowing 144 yards and a 4.5 average on 32 attempts. Gore was held to 81 yards and a 3.5 average on 23 attempts with a long of 11 yards, but he had a 4-yard touchdown run in the first quarter. Carlos Hyde had a 9-yard TD run in the opening period as well and finished with 36 yards and a long of 15 on four carries. Kaepernick was kept under control for most of the day, but did have a 19-yard run — the longest of the day for the 49ers — and had 24 yards on four attempts.

–SPECIAL TEAMS: B — Thomas Morstead punted six times for a 49.8 gross average and 42.0 net averaged with a long kick of 54 yards, while Shayne Graham made his only field-goal attempt from 40 yards out. The Saints again had trouble in the return game with Cooks getting just 4 yards on one punt return and Cadet averaging 24.0 yards on four kickoffs with a long of 29. The 49ers averaged 3.5 yards on two punt returns and 25.3 yards on four kickoffs.

–COACHING: B — Despite Sean Payton doing everything he can to push the right buttons, the Saints are failing this season to get over the hump in crunch time. They lost Sunday for the fourth time this season when they had a lead late in the fourth quarter, which means they could be 8-1 instead of 4-5. You still have to give Payton and his staff credit for keeping the game close, especially a defense that pitched a shutout for more than 33 minutes — allowing the offense to get back in the game — after the 49ers jumped out to a 21-10 lead in the second quarter.