OAKLAND — Quarterback Derek Carr passed for 254 yards and three touchdowns, tight end Mychal Rivera caught seven passes for a career-high 109 yards with one score, and the Oakland Raiders upset the San Francisco 49ers 24-13 Sunday at the O.co Coliseum.

The Raiders were coming off a 52-0 loss to the St. Louis Rams, but they won for the second time in three games. Oakland (2-11) delivered a painful blow to its Bay Area rivals’ playoff hopes.

The 49ers (7-6) lost their second game in a row, as they fell 19-3 to the Seattle Seahawks on Thanksgiving. San Francisco dropped three games behind the first-place Arizona Cardinals (10-3) in the NFC West.

Carr completed 22 of 28 passes and posted a passer rating of 140.2. He did not throw an interception. Oakland fullback Marcel Reece caught seven passes for 64 yards and a touchdown.

San Francisco quarterback Colin Kaepernick had another rough day, completing 18 of 33 passes for 174 yards and one touchdown. He was intercepted twice, sacked five times and had a 54.4 passer rating.

Niners wide receiver Michael Crabtree caught a game-high nine passes for 56 yards.

The 49ers snapped a 10-10 tie early in the third quarter, settling for Phil Dawson’s 20-yard field after stalling at Oakland’s 2-yard line.

The Raiders responded with an eight-play, 80-yard touchdown drive, and Carr hit Reece on a 9-yard scoring strike. Carr, getting great pass protection, completed all five of his throws on the drive for 71 yards. Lined up left, Reece beat 49ers cornerback Dontae Johnson on a slant, caught Carr’s pass at the 5 and raced into the end zone, giving Oakland a 17-13 lead with 4:09 remaining in the third.

The Raiders forced a punt and kept attacking. They marching 80 yards again for a touchdown to take a 23-13 lead on Carr’s 5-yard scoring pass to Rivera with 10:39 remaining. This time Carr went 6-for-7 for 83 yards.

The 49ers drove to Oakland’s 25, but on third-and-8, Raiders defensive tackle Antonio Smith sacked Kaepernick for a 4-yard loss. Dawson then hooked his 47-yard field attempt wide left with 5:03 remaining.

Oakland sealed the victory when free safety Charles Woodson picked off a Kaepernick pass, giving Oakland a first down at the 49ers’ 28 with 2:36 remaining.

On the game’s first play from scrimmage, Kaepernick scrambled left and overthrew Crabtree down the sideline. Strong safety Brandian Ross intercepted the pass, and the Raiders took over at their 49.

Oakland capitalized on Kaepernick’s mistake, taking a 3-0 lead when Sebastian Janikowski’s kicked a season-long 57-yard field with 11:46 left in the first quarter.

The 49ers moved ahead 7-3 on Kaepernick’s 8-yard touchdown pass to fullback Bruce Miller with 1:54 remaining in the opening quarter. Kaepernick faked a handoff to wide receiver Anquan Boldin, who lined up in the backfield, and hit a wide open Miller in the left flat. Miller turned upfield and scored standing.

Oakland turned to trickery for its first touchdown of the game as Carr hit offensive tackle Donald Penn on a 3-yard touchdown pass, putting the Raiders ahead 10-7 with 10:45 left in the half. Penn lined up as in eligible receiver on the left side, faked a block and slipped out to his left. He grabbed Carr’s low pass, withstood a hit from 49ers safety Eric Reid and bulled into the end zone.

The touchdown catch was the 6-foot-4, 320-pound Penn’s third of his career and second against the 49ers, and he celebrated by leaping into the “Black Hole” in the stands behind the south end zone.

Dawson had a 56-yard field goal nullified by a holding penalty on tight end Garrett Celek midway through the second quarter, but he hit a 52-yarder that counted with one second left in the half, making it 10-10.

NOTES: Niners starting CB Chris Culliver sustained an apparent left knee injury with 11:03 left in the first half and went to the locker room. … San Francisco LG Mike Iupati left the game late in the second quarter with an elbow injury and did not return. … San Francisco RT Anthony Davis (concussion) was inactive for the third consecutive game. Jonathan Martin make his third straight start in Davis’ place and eighth overall. … Struggling 49ers WR Brandon Lloyd was inactive, and WR Quinton Patton was active for the first time this season. Lloyd made two catches for 16 yards over the previous five games. … Raiders RT Menelik Watson (ankle, foot) was inactive. Khalif Barnes started at right tackle, and rookie Gabe Jackson started at left guard. … Raiders WR Denarius Moore was inactive for the second game in a row. … San Francisco OLB Ahmad Brooks’ starting streak ended at 60 games. Dan Skuta started.