ORCHARD PARK, N.Y. — Terry and Kim Pegula now own the Buffalo Bills on paper.

Tom Brady still owns them on the field.

The New England Patriots quarterback passed for 361 yards and four touchdowns Sunday in a 37-22 win over Buffalo at Ralph Wilson Stadium. Brady is now 23-2 in his career against the Bills.

“You’ve got to give credit to the whole offense,” Patriots coach Bill Belichick said. “We did a decent job of blocking up front, gave Tom enough time. The receivers made some good plays. Tom made some good reads and some good throws. It took everybody working together out there today. It’s not a one-man band.”

Wide receiver Brandon LaFell caught two touchdown passes and Stephen Gostkowski kicked three field goals of more than 40 yards as the Patriots (4-2) claimed sole possession of first place in the AFC East.

Wide receiver Julian Edleman caught nine passes for 91 yards and tight end Rob Gronkowski caught seven passes for 94 yards. LaFell had 97 yards receiving.

The Patriots won the game, but suffered some key losses. Starting linebacker Jerod Mayo and running back Stevan Ridley both left the game with knee injuries and left tackle Nate Solder was sent to the bench with a head injury.

The Bills (3-3) were playing for the first time since the Pegulas took ownership of the franchise.

Buffalo turned the ball over three times in the first half, which led to 13 Patriots points, and was penalized eight times for 107 yards.

“I think that’s the story of the day,” Bills tight end Scott Chandler said. “You’ve got to protect the ball, and obviously that was our Achilles heel today.”

Bills running back Anthony Dixon added, “Turnovers and you can’t win. Especially when the other team doesn’t turn the ball over at all. We got to get back in the lab. We got to work on that, and we will. We’ll come back stronger.”

Quarterback Kyle Orton threw for 299 yards, two touchdowns and an interception in his second start for Buffalo. Chandler caught six passes for a career-high 105 yards.

After a slow start, the Patriots scored on six of seven possessions before kneeling down in the final minute.

“I don’t think we’ve played to our potential yet,” Pats left tackle Nate Solder said. “That’s something we’re working on.

“Maybe next week.”

New England has a short turnaround before hosting the New York Jets on Thursday night. Buffalo hosts Minnesota next Sunday.

Brady iced the game with a 56-yard touchdown pass to LaFell that put the Patriots up by two touchdowns with 2:49 remaining in the game.

What the Patriots said:

“We are clicking as a team right now. We are clicking on offense and clicking on defense. We just have to keep it going and keep working hard.” — TE Rob Gronkowski.

What the Bills said:

“Turnovers and penalties. When you kill yourselves on drives like that, it’s going to be hard to get anything going. That was our M.O. today.” — RB Fred Jackson.

What we learned about the Patriots:

1. Tom Brady is as good as ever. Some doubted the 37-year-old quarterback after his pedestrian play during New England’s 2-2 start. In the Patriots’ past two victories, Brady has thrown for 653 yards, six touchdowns and no interceptions. On Sunday, he became the fifth player in NFL history with 60 career 300-yard passing games. “Just being around him gives you confidence,” wide receiver Brian Tyms said.

2. The victory was “a little bit bittersweet,” coach Bill Belichick said. Starting linebacker Jerod Mayo was carted off the field in the first half with a knee injury. Running back Stevan Ridley also went out with a knee injury, and left guard Dan Connolly was knocked out with a head injury.

–TE Rob Gronkowski has always tormented his hometown team. On Sunday, he caught seven of nine passes thrown his way for 94 yards and drew a 17-yard pass interference penalty on the Patriots’ third quarter field goal drive. Gronkowski also had an 18-yard touchdown pass called back due to a false start penalty in the fourth quarter.

–WR Brian Tyms emerged as another deep threat for New England. Tyms caught his first career touchdown pass, outmuscling Bills cornerback Stephon Gilmore to haul in a 43-yard bomb on the opening drive of the third quarter. Tyms was suspended for the first four games due to a violation of the NFL’s substance abuse policy, and was inactive last week.

–CB Darrelle Revis shut down the Bills rookie receiver Sammy Watkins, whom coach Bill Belichick had high praise for earlier in the week. Watkins caught just two passes for 27 yards. He was not targeted on a pass until late in the third quarter.

What we learned about the Bills:

1. New ownership may not mean a new era in Buffalo. The Bills celebrated the completion of Terry and Kim Pegula’s record $1.4 billion purchase of the franchise with a pregame ceremony and a surge of excitement from the sold-out crowd. But the emotional boost couldn’t carry the day for the Bills, who have lost 27 of their last 29 games against their AFC East rivals.

2. The Bills’ pass defense is not on par with its run defense. Buffalo came into the game ranked second in the NFL in allowing 71 rushing yards per game. New England rushed for 220 yards in last week’s win over Cincinnati. On Sunday, the Bills held New England’s running backs to just 37 yards on 21 carries and the Patriots 50 rushing yards total. But the Patriots were able to abandon the run and still move the ball effectively through the air.

–TE Scott Chandler caught six passes for a career-high 105 yards. The 6-foot-7 target became the first Bills tight end to top 100 receiving yards in a game since Pete Metzelaars had 113 on Sept. 13, 1992 at San Francisco.

–WR Mike Williams started the Bills’ first four games, but was a healthy scratch on Sunday. Coach Doug Marrone said it was a late decision due to defensive tackle Kyle Williams becoming available to play after missing last week with a knee injury, and the Bills wanting to have three tight ends active for the game.

–RB C.J. Spiller continued to struggle, gaining just 19 yards on six carries and losing a fumble late in the second quarter. Third-string running back Anthony Dixon had one more carry than Spiller, while Fred Jackson rushed 10 times. Spiller is averaging 39 yards per game and 3.4 yards per carry this season.