San Diego Chargers (5-2) at Denver Broncos (5-1)

Thursday, 8:25 p.m. ET, at Sports Authority Field at Mile High, Denver – TV: CBS

*TV announcers: Jim Nantz, Phil Simms, Tracy Wolfson

*Keys to the game: Undrafted rookie RB Branden Oliver continues to play well for the Chargers, who struggled to maintain drives last week. The result was just 15 carries for Oliver, and the offense bogged down when some makeable plays in the passing game went by the wayside due to off-target passes or miscommunication. San Diego must be committed to Oliver early on Thursday night to sustain drives and shorten the game for its defense, but also to help the offensive line to cope with OLBs Von Miller and DeMarcus Ware, the only tandem in the NFL to each have 7.0-plus sacks this season.

Peyton Manning has the Broncos’ offense humming at its best clip of the season. He’s picking apart teams that attempt to blitz, so the Chargers’ defensive line must get home. The problem is, that same defensive line is getting put on ice skates too often in the ground game. If RB Ronnie Hillman is adding a complement through the ground, Manning will pick apart a secondary thinned by injuries. Chiefs QB Alex Smith completed passes to eight different players last week against the Chargers, who are also now giving up 4.5 yards per carry on the season – a bad combination.

*Matchup to watch – Chargers DT Cory Liuget vs. Broncos interior offensive line: San Diego began last week’s game in the nickel package and will likely live in it against Manning. That puts a bigger weight on Liuget to clog up the running lanes and clear ILBs Donald Butler and Andrew Gachkar to make plays. Broncos LG Orlando Franklin wasn’t thrilled about moving inside this season, but has helped add bulk and physicality between the tackles.

*Player spotlight – Chargers CB Richard Marshall: With Brandon Flowers (concussion) likely out and Jason Verrett (shoulder) uncertain, Marshall is again in line for significant playing time, and he was attacked by Smith when in the game last week.

*Fast facts: The teams have split the past 10 regular-season meetings. … Manning has a 9-2 record on Thursday nights. … Chargers TE Antonio Gates needs 29 receiving yards to break Lance Alworth’s (9,584) career franchise record.

WHO WILL WIN AND WHY

The Chargers are only a half-game back despite last week’s setback against Kansas City. Unfortunately for the Chargers, they’re shorthanded on a short week, the Chiefs exposed some issues that weren’t readily seen against lesser competition and San Diego runs into a Denver buzz saw that won’t let up this week.

*Our pick: 33-23

Atlanta Falcons (2-5) vs. Detroit Lions (5-2)

Sunday, 9:30 a.m. ET, at Wembley Stadium, London — TV: FOX

*TV announcers: Thom Brennaman, Troy Aikman, Charissa Thompson

*Keys to the game: It’s Football 101, but the Falcons simply have to be productive on first and second down. With five offensive linemen on injured reserve, QB Matt Ryan doesn’t have the time to allow vertical routes to develop, so he needs the support of the ground game to set up manageable third downs. Problem is, Detroit enters with the league’s second-ranked run defense while the Falcons are averaging just 98.1 rushing yards per game — a figure bolstered by a few big runs from Antone Smith, who has only 16 carries on the season. Atlanta expects a heavy dose of man coverage as opponents sit on underneath routes, but WR Roddy White said it’s simply up to the Falcons’ receivers to win their battles and break tackles after the catch to help out their quarterback.

The Lions might be without WR Calvin Johnson (ankle) for the third consecutive game, but Golden Tate has stepped up in his absence and leads the team with 48 catches for 649 yards. That reliability has not been there in the past when Johnson was out of the lineup. Detroit’s offensive plan needs to be more safe than exotic, as QB Matthew Stafford threw a pair of interceptions last week. RB Joique Bell had 20 touches last week and will again combine with Reggie Bush to help control field position and force the Falcons to prove they can drive the length of the field.

*Matchup to watch — Lions DTs Nick Fairley and Ndamukong Suh vs. Falcons C James Stone/Harland Gunn: The Falcons will start their third different center of the season following season-ending injuries to Joe Hawley and Peter Konz. James Stone finished last week’s game, playing 56 of 66 offensive snaps, and has been working diligently with Ryan studying film. No film can prepare the undrafted rookie for the size, speed and strength the Lions’ interior tandem will bring Sunday. Gunn has also been taking snaps at center in the event the Falcons don’t feel comfortable going with Stone, who coach Mike Smith acknowledges, “just doesn’t have any experience.”

*Player spotlight — Lions DE Ziggy Ansah: He’ll face plenty of one-on-one opportunities against rookie Jake Matthews, who is battling a nagging ankle injury.

*Fast facts: Falcons DE Osi Umenyiora was born in London. … Tate has three 100-yard receiving games over the past four weeks.

WHO WILL WIN AND WHY

Since the injuries really started to mount four games ago, the Falcons’ have scored 28, 20, 13 and 7 points. The regression is stark, yet understandable. And playing the league’s top-ranked defense, which can dominate healthy offensive lines, isn’t going to help.

*Our pick: Lions 24-16

Baltimore Ravens (5-2) at Cincinnati Bengals (3-2-1)

Sunday, 1:00 p.m. ET, at Paul Brown Stadium, Cincinnati — TV: CBS

*TV announcers: Greg Gumbel, Trent Green, Evan Washburn

*Keys to the game: The Ravens have found the offensive balance that escaped them last season thanks to unlikely production from RB Justin Forsett, who enters averaging 5.8 yards per carry. That has alleviated pressure from QB Joe Flacco, who has been sacked just eight times. The offense has found its rhythm since a season-opening 23-16 home loss to the Bengals, as the Ravens have averaged 35.4 in the five ensuing games. Cincinnati’s defense has fallen to 31st in yards allowed while struggling through playing several youngsters due to injury and must avoid the assignment breakdowns that have led to far too many big plays on the ground.

The Bengals’ approach will hinge largely on the availability of WR A.J. Green (toe), who could be a game-time decision. With or without Green, QB Andy Dalton needs the ground game to get untracked and for the offensive line to hold the fort better after struggling mightily with the Colts’ speed packages last week, when Dalton was pressured on 30 percent of his dropbacks.

*Matchup to watch — Ravens NT Brandon Williams vs. Bengals C Russell Bodine: Bodine, a rookie out of North Carolina, gives up nearly 30 pounds in this battle, and will work with OGs Clint Boling and Kevin Zeitler in an attempt to move Williams and clear more running lanes than the Bengals’ backs have seen in recent weeks.

*Player spotlight — Bengals WLB Vontaze Burfict: It was back to basics for Burfict this week after he was forced out of last Sunday’s game due to a neck injury. Bengals defensive coordinator Paul Guenther is stressing tackling with his head up, as Burfict has managed to play in just 33 percent of the defensive snaps this season. The Ravens had 77 yards in the 29 minutes Burfict played in the opener, but 232 in the 31 minutes after he left with a concussion.

*Fast facts: The Bengals will play home games three consecutive weeks for the first time since 1997. … Sunday will mark the first time since 1974 Cincinnati will finish a season series against a division rival before playing another team from within its division.

WHO WILL WIN AND WHY

As poorly as they have play over the past three games, the Bengals are 11-0-1 in their past 12 home games and are desperate to avoid falling three games behind the Ravens. Of course, having Green available would help immensely in that effort.

*Our pick: Bengals 26-21

Buffalo Bills (4-3) at N.Y. Jets (1-6)

Sunday, 1:00 p.m. ET, at MetLife Stadium, East Rutherford, N.J. – TV: CBS

*TV announcers: Kevin Harlan, Rich Gannon

*Keys to the game: Buffalo bounds into New Jersey with a backfield consisting of players who might have needed nametags to be recognized by most of the Bills’ offense a month ago. With Fred Jackson (groin) and C.J. Spiller (collarbone) out, Anthony Dixon is likely to start and share the load with the more explosive Bryce Brown. QB Kyle Orton was sacked six times last week, a fact that has Jets coach Rex Ryan licking his chops to unleash a blitz-heavy attack. To calm the wobbly offensive line and protect himself, Orton is unlikely to launch many deep throws and lean on his backup running back tandem to move the chains. Orton is third in the NFL with a 68.5 completion percentage because he works within his comfort zone — passes of 7-15 yards.

The Bills are having no issue getting the quarterback, but must gear up to corral RB Chris Ivory, who found his legs against New England with a 107-yard game. The Vikings found inside running lanes to exploit last week but Buffalo is fourth in the NFL against the run at 80 yards per game. If they hem in the running game, QB Geno Smith will be tested. The Bills lead the NFL in sacks with 24, and if they can generate pressure against a veteran Jets offensive line, Smith shows questionable decision-making and has nine turnovers while taking 15 sacks in seven games.

*Matchup to watch – Bills OGs Erik Pears and Kraig Urbik vs. Jets DL Sheldon Richardson and Muhammad Wilkerson: Urbik was reinserted to the starting lineup at left guard this week for Cyril Richardson. ProFootballFocus.com rates the Bills’ guard play as the NFL’s worst by a wide margin. Richardson and Wilkerson can win with power and agility, and against Ryan’s blitz packages, there is little help to offer inside.

*Player spotlight – Jets WR Percy Harvin: At halfback, wide receiver and on returns, Harvin’s speed invites attention. As a decoy or in a select package of plays, the Jets’ need for playmakers is too steep not to involve the 26-year-old newcomer as heavily as possible.

*Fast facts: New York is the only team in the AFC East the Bills have an all-time winning record against, but the Jets have won four in a row in New Jersey. … Wilkerson has 9.5 sacks in his past 11 home games.

WHO WILL WIN AND WHY

Well rested and fighting for positives to snap a six-game losing streak, the Jets find points on special teams and defense to win for the first time since Sept. 7.

*Our pick: Jets 22-20

Chicago Bears (3-4) at New England Patriots (5-2)

Sunday, 1:00 p.m. ET, at Gillette Stadium, Foxborough, Mass. — TV: FOX

*TV announcers: Sam Rosen, John Lynch, Pam Oliver

*Keys to the game: The Bears chalked last week’s post-game locker room drama involving WR Brandon Marshall calling out good friend QB Jay Cutler to heat-of-the-moment passion. But the fact is that Cutler has multiple turnovers in each of Chicago’s four losses and one total in their three victories. RB Matt Forte continues to lead the league in catches, and coach Marc Trestman needs to be consistent in getting him touches to keep the chains moving and Cutler out of the pressure that leads to so many of his mistakes. The Patriots will be minus sack leader Chandler Jones (4.5).

New England continues to shuffle its offensive line due to injuries and effectiveness, but the pressure on QB Tom Brady has subsided significantly from the start of the season. The Patriots had 37 pass attempts vs. 15 rushes last week, but the underneath passing attack complements the ground game and Shane Vereen’s versatility led to leading the team with 43 rushing and 71 receiving yards in Week 6. The Bears can bring pressure from all four spots up front, but the rushers must be cognizant of Vereen and WR Julian Edelman in motion slipping out of the backfield and generating big plays. Rob Gronkowski could feast on a defense allowing almost 15 yards per catch to tight ends.

*Matchup to watch — Marshall vs. Patriots CB Brandon Browner: Much was made of Marshall’s five-inch height advantage over Dolphins CB Cortland Finnegan last week, but Marshall finished with just 48 yards while catching six of the 10 passes thrown his way. Browner (6-4, 221) is nearly the physical identical to Marshall, but showed significant rust last week in his first game back from suspension and injury. Browner played 41 snaps and was called for two penalties, but his workload should ramp up this week.

*Player spotlight — Patriots RB Jonas Gray: Promoted from the practice squad hours before New England’s Week 7 victory over the Jets, the former undrafted rookie had three carries for 12 yards while seeing 17 combined snaps on offense and special teams. At 5-10, 225 pounds, coach Bill Belichick likes his size as a complement to the 205-pound Vereen.

*Fast facts: Chicago’s opponents have scored a total of 37 points off Cutler’s turnovers this season. … Edelman has caught at least four passes in 13 consecutive games.

WHO WILL WIN AND WHY

The Patriots have a 12-game home winning streak and Brady has found a smooth rhythm with his reworked receiving corps. The Bears are alternately explosive and inconsistent on offense, and have too many breakdowns defensively to knock off one of the AFC’s better teams on the road.

*Our pick: Patriots 27-24

Houston Texans (3-4) at Tennessee Titans (2-5)

Sunday, 1:00 p.m. ET, at LP Field, Nashville – TV: FOX

*TV announcers: Kenny Albert, Daryl Johnston, Tony Siragusa

*Keys to the game: A revived Arian Foster is the last thing Tennessee wants to see right now. The Titans are a dust storm of injuries and lineup changes as they spiral toward a third consecutive losing season. Foster is averaging 102.5 yards per game on the ground and is getting yards in bunches with 16 carries of at least 10 yards. Strong starts have been common under the heavily scripted Bill O’Brien’s watch — Houston led 13-0 in the second quarter Monday before falling at Pittsburgh — and the Titans have been outscored 37-13 in the first quarter.

Watch for QB Ryan Fitzpatrick, who started 10 games for the Titans last season, to throw on first down to take advantage of the Titans’ scheme slanted to stop Foster, then use play-action to take his shots down the field. LG Ben Jones will be largely responsible for keeping Titans DL Jurrell Casey (14.5 sacks in his past 20 games) at bay.

The Titans are turning to Zach Mettenberger, the third starting quarterback for the team this season, as Jake Locker isn’t ready to come back from a three-game absence because of a thumb injury and the team wants to get a good look at the rookie. The Titans will feature the running game, but the Texans are going to stack the line to challenge the confident Mettenberger to throw over the top. Third downs are the ongoing bugaboo for Tennessee, which is just 19 for 67 since Week 1.

*Matchup to watch – Titans LT Taylor Lewan vs. Texans OLB Jadeveon Clowney: With Mettenberger likely to see exotic looks designed to confuse, the Texans could slide the pass rushers around. Clowney, the first overall pick in the 2014 draft, and Lewan (11th) have tangled before, in the 2013 Outback Bowl between Michigan and South Carolina when Clowney made the infamous helmet-propelling hit on RB Vincent Smith. Lewan is making his third consecutive start. Clowney returned to practice this week. The coaches are hoping he can return and play 20 to 30 snaps on passing downs to work his way back into football shape on the weak side.

*Player spotlight – Texans WR Andre Johnson: The all-time great has been quiet against the Titans, but Tennessee now lacks a lock-down cover man. Johnson has gone seven games since scoring in the series (Dec. 19, 2010), but seemed to click with Fitzpatrick late in last week’s game.

*Fast facts: The Texans have 17 losses since the start of last season — 12 by seven or fewer points. … The Titans have one first-quarter touchdown and two in the fourth quarter this season.

WHO WILL WIN AND WHY

Unable to sustain drives and cash in red-zone chances, the Titans must gamble to get an upper hand. Coach Ken Whisenhunt and Tennessee are whiffing at a high percentage, leaving the door open for Houston to land the knockout blow.

*Our pick: Texans 21-13

Miami Dolphins (3-3) at Jacksonville Jaguars (1-6)

Sunday, 1:00 p.m. ET, at EverBank Stadium, Jacksonville, Fla. — TV: CBS

*TV announcers: Andrew Catalon, Steve Tasker, Steve Beuerlein

*Keys to the game: The Dolphins continue to run the ball very effectively — averaging 136.3 yards per game despite the season-ending injury to Knowshon Moreno. Third-year back Lamar Miller remains undersized for a true lead back role, but has improved his blocking and receiving skills, and the ground attack is complemented by Daniel Thomas and quarterback Ryan Tannehill, who scampered for 30 yards on a read-option on 3rd-and-1 last week. The versatility of the ground game is working to keep the pressure of Tannehill to make pinpoint passes, though he hit 14 in a row last week for the second time this season. The Jaguars’ defense is steadily improving as several new parts begin to mesh, and the 15th-ranked run defense must step up against Miller despite the season-ending injury suffered by MLB Paul Posluszny last week.

Former Michigan quarterback Denard Robinson is the new best friend of Jaguars rookie QB Blake Bortles after rushing for 127 yards on 22 carries last week. It served as the long-awaited help from the ground game that Bortles desperately needs to keep the chains moving. The Dolphins sport a deep and fast defensive line capable of blowing up the pocket, so Jacksonville must stay in manageable down and distances.

*Matchup to watch — Dolphins Ss Louis Delmas and Reshad Jones vs. Jaguars TE Clay Harbor: Miami interchanges its safeties, and Delmas and Jones will alternate staying back and moving forward in run support depending on the situation. Jones has been lauded by the coaching staff for his performance in two games since returning from suspension, including 16 tackles and a pick. Harbor is emerging as Bortles’ safety blanket in the absence of injured Marcedes Lewis, catching all six of his targets last week for 34 yards following his first touchdown of the season in Week 6.

*Player spotlight — Dolphins WR Jarvis Landry: The rookie from LSU continues to develop as one of Tannehill’s favorite targets. Landry has 22 receptions for 232 yards and one touchdown — three more receptions and 37 more receiving yards than veteran Brian Hartline, who logs far more snaps.

*Fast facts: The Dolphins have lost 11 player games to suspensions this season. … The Jaguars’ defense is second in the NFL with 22 sacks.

WHO WILL WIN AND WHY

Miami has quietly played three very solid games in a row and has the defensive line depth to pressure Bortles (5 TDs, 10 INTs) into multiple mistakes.

*Our pick: Dolphins 26-16

Minnesota Vikings (2-5) at Tampa Bay Buccaneers (1-5)

Sunday, 1:00 p.m. ET, at Raymond James Stadium, Tampa — TV: FOX

*TV announcers: Justin Kutcher, David Diehl, Laura Okmin

*Keys to the game: The Vikings hit the road determined to improve the protection for rookie quarterback Teddy Bridgewater, who has been sacked 13 times the past two weeks. They will also see former head coach Leslie Frazier, who now oversees a Bucs defense ranked last in points allowed (34.0 per game), total yardage (422.8) and pass defense (294.5). Tampa Bay ranks 25th in sacks per pass play, and no individual has more than two. That’s music to the ears of the Vikings’ offensive line, which ranks last in sacks allowed per pass play.

The Bucs had a bye week to digest their latest embarrassing effort, a 48-17 setback to the Ravens in Week 6. For Tampa Bay to push the game into the fourth quarter, it must run the ball effectively behind Bobby Rainey, who has been far more effective than Doug Martin (2.9 yards per carry). QB Mike Glennon has played well at times, but the offensive line doesn’t hold protection for long. A quick start is critical — Glennon has a 30.2 passer rating on his first 10 pass attempts of games and the Bucs have too often found themselves staring at massive early deficits.

*Matchup to watch — Vikings LT Matt Kalil vs. Bucs DE Michael Johnson: Kalil is tied for the league lead in both sacks allowed (eight) and pressures (27). Johnson is tied for the team lead in sacks, but that’s not saying much with just 2.0. The Bucs clearly expect more production for the five-year, $43.75 million deal they gave Johnson over the offseason.

*Player spotlight — Vikings RB Jerick McKinnon: The former triple-option quarterback at Georgia Southern has impressed with his big-play potential and averaged 5.1 yards per carry. However, at just 5-9 while still learning the intricacies of the position, he also ranks as the league’s worst pass-blocking back, according to Pro Football Focus.

*Fast facts: The Bucs have won the past six meetings dating back to 2002, the final season the teams were NFC Central rivals. … McKinnon has been charged with two sacks allowed and five pressures in 24 snaps as a pass protector, per Pro Football Focus.

WHO WILL WIN AND WHY

Bridgewater has shown poise and good decision-making when given decent time to survey the field. The Bucs don’t rush the passer well, and therefor are limited in their ability to exploit the Vikings’ biggest weakness.

*Our pick: Vikings 28-20

St. Louis Rams (2-4) at Kansas City Chiefs (3-3)

Sunday, 1:00 p.m. ET, at Arrowhead Stadium, Kansas City, Mo. — TV: FOX

*TV announcers: Dick Stockton, Donovan McNabb, Kristina Pink

*Keys to the game: The Rams are increasingly relying on their impressive rookie class, including RB Tre Mason, who logged 18 carries for 85 yards against Seattle last week. Second-year QB Austin Davis, who had struggled with bouts of poor decision making under pressure, thrived with a more conservative game plan as he completed 17 of 20 passes and a pair of touchdowns. Twelve of those completions went to backs and tight ends. The Rams will be content to play a field position game and rely on their high risk/high reward special teams to come up with a game-changing play or two.

Chiefs QB Alex Smith has an enormous experience edge on his counterpart and has been playing excellent football over the past month. He, too, will take what the defense gives him as Kansas City has no desire to let the Rams’ resurgent defensive line dictate the game. Smith has to be careful against St. Louis’ aggressive young secondary that tends to gamble — leading to big plays one direction or the other. RBs Jamaal Charles and Knile Davis combined for 35 touches last week and are the best counter-weapons to a d-line that likes to get upfield, often leaving the league’s 28th-ranked run defense exposed.

*Matchup to watch — Rams DT Aaron Donald vs. Chiefs RG Zach Fulton: Donald worked his way into the starting lineup two games ago and wreaked all kinds of havoc against Seattle last week, including five tackles and a sack. Fulton is a sixth-round rookie who has started all six games, but is still learning on the fly. He’ll have a difficult time contending with the quickness of the 6-1, 285-pound Donald, but the Chiefs will be hard-pressed to protect Fulton much while also coping with Robert Quinn, Michael Brockers and William Hayes up front.

*Player spotlight — Rams LG Greg Robinson: Robinson also moved into the starting lineup two weeks ago. At 6-5, 332, his future is at left tackle while the Rams give the 22-year-old a softer landing spot inside. Raw but supremely athletic for his size, Robinson has upgraded the interior run-blocking.

*Fast facts: Rams leading rusher Zac Stacy (240 rushing yards) logged only one offensive snap last week and had no carries. … Smith has a 110.4 passer rating with eight TDs and 1 INT over his past three games.

WHO WILL WIN AND WHY

The Rams unloaded the special teams bag of tricks at home last week and still barely held off rival Seattle. On the road against a solid playoff contender, St. Louis’ youth is too much to overcome in the din of Arrowhead.

*Our pick: Chiefs 28-20

Seattle Seahawks (3-3) at Carolina Panthers (3-3-1)

Sunday, 1:00 p.m. ET, at Bank of America Stadium, Charlotte — TV: FOX

*TV announcers: Ian Eagle, Dan Fouts, Jenny Dell

*Keys to the game: The Seahawks are eager to see if the offensive chemistry that developed over the second half of last week’s loss at St. Louis carries over. Following the Percy Harvin trade, Seattle is focused on returning to a run-first scheme that filters in the read-option with QB Russell Wilson when teams overplay RB Marshawn Lynch. One area of concern is fullback, where Lynch’s backup, Robert Turbin, saw snaps for the first time in his life after Derrick Coleman suffered a broken foot in pre-game warmups last week. Turbin could see more action as a lead-blocker Sunday, which in turn would lead to more carries for Christine Michael.

WR Doug Baldwin caught seven passes for 123 yards and a touchdown back in the slot position he produced from so consistently last season. Carolina’s run defense has plummeted to 26th, but the Panthers will attempt to bottle up Lynch and Wilson between the tackles and force the Seahawks’ receivers to gain separation.

Seattle’s coaches have taken note of the improved mobility shown by Panthers QB Cam Newton in recent weeks. Carolina is still searching for a more consistent ground presence with Jonathan Stewart averaging just 3.8 yards per carry last week, and gaining positive yardage on first and second down will be key. The Seahawks have struggled to generate pressure much of the season, but coach Pete Carroll indicated tweaks to the scheme to free up pass rushers — potentially through increased blitzes.

*Matchup to watch — Seahawks CB Richard Sherman vs. Panthers WR Kelvin Benjamin: The rookie Benjamin leads Panthers wide receivers with 34 catches for 477 yards and five touchdowns. At 6-5, 240, he presents an interesting physical matchup for the 6-3, 195-pound Sherman, who has yet to record an interception this season.

*Player spotlight — Seahawks DL Michael Bennett: The team’s most consistent pass rusher last season, Bennett has three of the team’s seven sacks this season but Carroll is looking to spring him for more pressure with increased snaps inside on passing downs.

*Fast facts: Wilson has won both career meetings against Carolina. … The Panthers have allowed 37-plus points in four of their past five games and a total of 195 through seven games. They allowed 241 all of last season.

WHO WILL WIN AND WHY

Both teams rolled through the regular season to earn first-round byes in 2013 but enter this week battered, bruised and in need of a victory to avoid slipping further behind in the NFC. The defending champs showed life in the second half last week — something the Panthers’ defense hasn’t displayed in more than a month.

*Our pick: Seahawks 27-23

Philadelphia Eagles (5-1) at Arizona Cardinals (5-1)

Sunday, 4:05 p.m. ET, at University of Phoenix Stadium, Glendale, Ariz. – TV: FOX

*TV announcers: Chris Myers, Ronde Barber, Jennifer Hale

*Keys to the game: The Cardinals are third in the NFL with a plus-seven turnover ratio, which keeps them in every game and pinches opponents who are loose with the ball. The Eagles (minus-1) spread the ball around but their pace-based offense thrives on the running game. It finally got what was expected of LeSean McCoy, who averaged 95.3 yards from scrimmage in three career games against the Cardinals, before the bye week.

The Eagles are known for their shotgun offense, but QB Nick Foles was under center for 22 of 71 offensive plays in Week 6. Thirteen of those plays were McCoy runs, providing him more time to read the defense and for coach Chip Kelly to implement more cut-back runs to keep the defense honest.

Cardinals QB Carson Palmer is 10-2 in his past 12 starts and while he’s not running the level of flammable offense Foles does for the Eagles, Palmer has settled in as a perfect extension of coach Bruce Arians. While veering away from LB Connor Barwin (six sacks in his last three games), Palmer should have time to look for his diverse collection of pass catchers. Jitterbug rookie WR John Brown is elusive after the catch but the Eagles will try to stick him off the snap to disrupt Palmer’s timing. The Eagles expect to be in plenty of nickel and dime packages with Arizona’s ability to go to four- and five-receiver sets.

*Matchup to watch – Cardinals RB Andre Ellington vs. Eagles LB Mychal Kendricks: Philadelphia’s top defensive player could return just in time for a grueling workout, shadowing three-down back Ellington and emerging backup Stepfan Taylor, the focal points of the Arizona offense who are more dangerous as receivers than runners. *Player spotlight – Eagles TE Zach Ertz: So committed to the running game are the Eagles that they’ve moved away from Ertz in base packages, leaving him to play just over half of the offensive snaps because he is a liability as a blocker. But he’s also a knockout in the red zone and caught two touchdowns last season in a win over Arizona.

*Fast facts: Of the teams to start 6-1 since the 1970 merger, 89 made the playoffs, only 17 did not. … The Eagles have converted just 40 percent of their red-zone opportunities into touchdowns. In the past 10 years, only one team has reached the postseason with a red-zone touchdown rate lower than 40 percent.

WHO WILL WIN AND WHY

Arizona’s underrated home-field edge could come into play but only if the steady Cardinals keep the game close into the fourth quarter. A back-and-forth game would eventually see the Cardinals tap out.

*Our pick: Cardinals 27-23

Indianapolis Colts (5-2) at Pittsburgh Steelers (4-3)

Sunday, 4:25 p.m. ET, at Heinz Field, Pittsburgh – TV: CBS

*TV announcers: Jim Nantz, Phil Simms, Tracy Wolfson

*Keys to the game: Blitzburgh no more, the Steelers are trying to find pressure without further loosening a defense that has many gaps. Head coach Mike Tomlin sees Andrew Luck as a more dangerous quarterback when he escapes the pocket and coverage breaks down. The Steelers will drop seven or eight and try to find a hot hand among CBs William Gay, Brice McCain and Cortez Allen to contain the AFC’s leading receiver, T.Y. Hilton (47 receptions for 711 yards).

The two teams to beat Luck’s bunch this season — Denver and Philadelphia — outscored the Colts. That’s easier said than done, considering the Colts limit opponents to a 26 percent conversion rate on third down and have 21 sacks and 12 takeaways. Steelers QB Ben Roethlisberger’s offensive line is spotty, but it can plow, and the team’s top two backs are over 5.0 yards per carry. Starter Le’Veon Bell was held in check Monday by the Texans but broke loose catching passes, an avenue that could open again this week facing a 3-4 defense for the fifth time in eight games.

*Matchup to watch – Colts CB Vontae Davis vs. Steelers WR Antonio Brown: Brown needs more help, but his production and reliability are the one constant for the Steelers. Roethlisberger looks for Brown first and Davis, one of the most underrated cover men in the NFL, has speed and the strength to redirect at the line.

*Player spotlight – Colts WR Donte Moncrief: The speedy rookie, along with Hakeem Nicks, will see more targets this week with Reggie Wayne (elbow) likely to be limited or out. Moncrief caught nine of 11 passes Luck threw in his direction through the first seven games.

*Fast facts: With a win, Roethlisberger would have 100 wins in 150 career starts. … The Steelers have won eight of the past 10 meetings. … Luck is gunning for a franchise-record sixth consecutive 300-yard passing game.

WHO WILL WIN AND WHY

Bell becomes the focal point for the Steelers, who grind out a home victory to set up a primetime slugfest with AFC North rival Baltimore in Week 9.

*Our pick: Steelers 27-23

Oakland Raiders (0-6) at Cleveland Browns (3-3)

Sunday, 4:25 p.m. ET, at FirstEnergy Stadium, Cleveland – TV: CBS

*TV announcers: Spero Dedes, Solomon Wilcots

*Keys to the game: Injuries at the heart of the offensive and defensive lines caused a major letdown at Jacksonville last week and the Browns are still making adjustments. The massive defensive line combo of Phil Taylor and Ahtyba Rubin is unlikely to be back, which suits the Raiders just fine. Interim head coach Tony Sparano wants to be physical and establish the run, and Cleveland was flattened by a weakling running game of the Jaguars a week ago. A steady diet of Darren McFadden will be thrown at the Browns’ 32nd-ranked run defense (155.2 yards per game), until they establish they can stop Oakland’s downhill attack.

Raiders rookie QB Derek Carr is becoming a strong leader with poise and presence despite a lackluster supporting cast. The Browns are solid in the secondary but with a makeshift front seven, Carr could have more time to pick his spots.

The Browns have a no-nonsense rushing attack ranked sixth in the NFL at 133.5 yards per game and use their backs to finish drives with a league-best eight touchdowns. Jacksonville thwarted the inside running game with speed, and took away the anticipated counter-punch of play-action passes from Brian Hoyer. Hoyer is just 24 for 58 in the past two games, and an early bout of inaccuracy could bring Johnny Manziel into the equation. Watch for TE Jordan Cameron, who has just 10 catches all season, to be heavily targeted in the first half.

*Matchup to watch – Browns FS Tashaun Gipson vs. Carr: Carr is careful with the ball. The rookie second-round pick has thrown eight touchdowns compared to five interceptions in six games. Gipson preys on mistakes and forced throws with four interceptions already in 2014 – three a direct byproduct of QB pressures – and seven picks in his past nine games.

*Player spotlight – Raiders DE Benson Mayowa: With LaMarr Woodley (biceps) out the Raiders will turn back to Mayowa, a noted athlete with pass-rushing skills who was strong against the run last week when Woodley went down. He spent last season with the Seattle Seahawks and made the Raiders primarily because of his athleticism. “You have to do it all,” Mayowa said. “You can’t be a one-trick horse these days. To stay around, it’s play all three downs.”

*Fast facts: The Browns have won five of the past seven meetings. … Raiders PK Sebastian Janikowski has 46 career field goals of 50-plus yards, six shy of Jason Hanson’s NFL record.

WHO WILL WIN AND WHY

Cleveland gets back to the winning ground game to move over .500 with another one-win team (Tampa Bay) visiting next week.

*Our pick: Browns 27-20

Green Bay Packers (5-2) at New Orleans Saints (2-4)

Sunday, 8:30 p.m. ET, at Mercedes-Benz Superdome, New Orleans – TV: NBC

*TV announcers: Al Michaels, Cris Collinsworth, Michele Tafoya

*Keys to the game: Unleashing Eddie Lacy on the ground in front of a big throng of family and friends as he plays his first NFL game not far from his New Orleans-area home would make for a nice story. Yet, QB Aaron Rodgers, who has an 18-1 TD-to-INT ratio, and his potent receiving cast led by Jordy Nelson and Randall Cobb will look to go to town against the Saints’ injury-ravaged pass defense, provided the quarterback is able to continue to dazzle inside and outside the pocket in the face of New Orleans’ exotic pressure packages.

Saints defensive coordinator Rob Ryan will get some notes from his brother Rex, whose Jets defense sacked Rodgers a season-high four times — but was toasted for three TDs and 346 yards.

Drew Brees has enjoyed meetings with Rodgers, throwing for no less than 323 yards in all three head-to-head matchups. But to give his defense a breather, Brees and the Saints must get the ground game going. RB Pierre Thomas is gone for 2-4 weeks with a shoulder injury, putting the onus back on Mark Ingram in his second week back from a month-long absence with a thumb injury. The Packers are 31st in the NFL at 147.9 rushing yards per game allowed. Ingram and Khiry Robinson would love to see TE Jimmy Graham (shoulder) back on the field, the one player the Packers defense would follow with multiple defenders, but his availability is highly questionable.

*Matchup to watch – Packers WR Randall Cobb vs. Saints DB Rafael Bush: Bush is a safety who plays the slot in nickel packages. He could be in for a long night the way Cobb is piling up numbers. He leads all receivers with a career-best eight touchdowns.

*Player spotlight – Saints LT Terron Armstead: In just his eighth career start, Armstead’s feet are held to the fire against a four-linebacker rotation that features Julius Peppers and Clay Matthews. Armstead is quick and athletic, but he’ll also need supreme discipline with little help expected on the flanks.

*Fast facts: Rodgers enters with no interceptions in his past six games, tying Pro Football Hall of Famer Bart Starr’s 50-year-old team record. … The Saints are 6-0 in home Sunday night games and have won 19 straight in the building with coach Sean Payton on the sidelines.

WHO WILL WIN AND WHY

New Orleans is more desperate but ill-equipped to withstand a shootout with the Packers unless Graham can have an impact and the defense shows more fight than it has to date.

*Our pick: Packers 34-24

Washington Redskins (2-5) at Dallas Cowboys (6-1)

Monday, 8:30 p.m. ET, at AT&T Stadium, Arlington, Texas – TV: ESPN

*TV announcers: Mike Tirico, Jon Gruden, Lisa Salters

*Keys to the game: Whether Colt McCoy or rehabbing Robert Griffin III gets the nod, the Redskins are intent on getting more out of the running game. Alfred Morris averages 120.5 rushing yards in four career games against the Cowboys, but Rod Marinelli’s Dallas defense is playing as if all the chips are on the table each week, spearheaded by MLB Rolando McClain.

McCoy won’t challenge much downfield but Dallas remains vulnerable at safety, and the Redskins could get Jordan Reed and Niles Paul on the field together at full strength for the first time in six weeks.

The Cowboys have a six-game winning streak on the legs of RB DeMarco Murray, the NFL’s leading rusher with 913 yards and seven touchdowns. Even if Murray isn’t on his game, the Cowboys should thrive passing the ball downfield against a spackled-over secondary.

*Matchup to watch – Cowboys WR Dez Bryant vs. Redskins CB Bashaud Breeland: Epic and entertaining one-on-one matchups with DeAngelo Hall made this rivalry one to watch in recent seasons. Hall is gone for the year and the Washington cornerback crew has been smoked repeatedly. Breeland, a rookie, could get the nod over David Amerson. The other doesn’t get a picnic either, covering Terrance Williams, who averages 17.8 yards per catch.

*Player spotlight – Redskins LB Trent Murphy: The second-round pick might not be ready to start, but here he comes with Brian Orakpo gone for the season. Murphy has short-area burst and stamina, but rushing from the right side against Cowboys LT Tyron Smith has been futile for most foes over the past two seasons.

*Fast facts: Washington is minus-9 in turnover margin. … Bryant has 27 touchdowns in his past 31 games. … Dallas has won five of the past seven meetings. … Griffin III had four TD passes and 304 yards in his previous MNF start at Dallas.

WHO WILL WIN AND WHY

While the Redskins search for an identity under coach Jay Gruden, the Cowboys establish the run quickly and have their way with a Washington defense waylaid by injuries.

*Our pick: Cowboys 31-17