BLACKSBURG, Va. — East Carolina scored three first-quarter touchdowns and held on in a 28-21 upset win over No. 17 Virginia Tech at Lane Stadium on Saturday.

Pirates quarterback Shane Carden broke the school record for career completions and career touchdowns in the win. The senior completed 23 of 47 passes for 427 yards and three touchdowns.

Carden, a senior, ran for the 1-yard game-winning touchdown with 16 seconds remaining, only moments after the Hokies tied it up on an 18-yard touchdown pass from quarterback Michael Brewer to freshman wide receiver Cam Phillips.

East Carolina wide receiver Cam Worthy had six catches for 224 yards. Bryce Williams, Trevon Brown and Isaiah Jones all had touchdown catches for the Pirates (2-1).

Brewer passed for 298 yards, three touchdowns and two interceptions on 30-of-55 passing. Hokies tailback Marshawn Williams rushed for 74 yards and 17 carries.

Virginia Tech (2-1) looked completely out of sorts at the start, only one week over a big road victory over Ohio State.

No. 2 Oregon 48, Wyoming 14

EUGENE, Ore. — Oregon junior quarterback Marcus Mariota passed for 221 yards and two scores, and ran for 71 yards and two touchdowns to lead Oregon over Wyoming in front of 56,533 in the 99th consecutive sellout at Autzen Stadium.

Mariota completed 19 of 23 passes and became the fourth Oregon quarterback to pass for 7,000 yards in his career. He had five carries, and two of them ended in the end zone, as he remained one of the frontrunners for the Heisman Trophy.

Mariota left the game early in the third quarter with Oregon (3-0) leading 41-7.

Oregon fell behind 7-0 after the first quarter, but scored 41 points in under 20 minutes to blow the Cowboys (2-1) away in the middle of the third quarter.

No. 20 Missouri 38, Central Florida 10

COLUMBIA, Mo. — Maty Mauk threw four touchdown passes, two each to Jimmie Hunt and Bud Sasser, and passed for 144 yards to lead Missouri past Central Florida.

The Tigers (3-0) led 14-10 at halftime before pulling away from the Knights.

Mauk finished the game with 174 total yards, completing 14-of-24 passes for 144 yards, with one interception.

Quarterback Justin Holman threw for 209 yards and one touchdown in his first career start for Central Florida (0-2).

Virginia 23, No. 21 Louisville 21

CHARLOTTESVILLE, Va. — Virginia used a 42-yard field goal by kicker Ian Frye late in the game to upset Louisville.

It was the Cavaliers’ first ACC victory since Nov. 10, 2012 when they knocked off Miami 41-40.

Wide receiver James Quick of Louisville (2-1) muffed a punt with under six minutes remaining to set up Virginia (2-1) with good field position where it would convert on the eventual game-winning kick.

The Cardinals turned the ball over four times.

No. 22 Ohio State 66, Kent State 0

COLUMBUS, Ohio — After a stunning loss at home to Virginia Tech last week, Ohio State took it to overmatched in-state opponent Kent State in a big way.

The Buckeyes scored on seven of their eight first-half possessions and rolled to an easy victory before 104,404 in Ohio Stadium.

Redshirt freshman quarterback J.T. Barrett, in his third start as the replacement for injured Braxton Miller, turned in the best performance of his young career by far. A week after completing only 9 of 29 passes against Virginia Tech, Barrett connected on 23 of 30 for 312 yards and six touchdowns with one interception.

Ohio State (2-1) punted only once against Kent State (0-3), with 6:05 left, and finished with 628 yards.