DETROIT — Dan Carpenter made a 58-yard field goal with four seconds left to give the Buffalo Bills a 17-14 win over the Detroit Lions Sunday afternoon at Ford Field.

Carpenter’s game winner came 17 seconds after Detroit kicker Alex Henery missed his third field goal of the half, a 50-yard try.

Kyle Orton, who only started one game the past two seasons as Dallas’ backup quarterback, completed 30 of 43 yards for 308 yards and a touchdown in his first start of this season for Buffalo (3-2). Orton replaced 2013 No. 1 draft pick E.J. Manuel, who was benched.

Running back Fred Jackson gained 50 yards on 11 carries and caught seven passes for 58 yards for the Bills and rookie receiver Sammy Watkins caught seven passes for 87 yards. Defensive tackle Marcell Dareus recorded a career-high three sacks.

Detroit cornerback Rashean Mathis had a 41-yard interception return for a touchdown.

Lions quarterback Matthew Stafford completed 18 of 31 passes for 167 yards and a touchdown. He was sacked six times under the aggressive schemes designed by Bills defensive coordinator and former Lions head coach Jim Schwartz.

Wide receiver Golden Tate caught seven passes for 134 yards and a touchdown for Detroit (3-2).

Hobbled by a right ankle injury, All-Pro wide receiver Calvin Johnson was limited to one reception for seven yards. Johnson re-aggravated the injury on the third-down catch and did not return.

Lions running back Reggie Bush was held to 13 yards on six carries before exiting with an ankle injury during the second half.

Buffalo was penalized nine times in the first half, helping the Lions take a 14-3 halftime lead.

A 28-yard screen pass to Bush set up the Lions’ first score, a 9-yard pass from Stafford to Tate with five seconds left in the opening quarter. The Lions appeared to score a play earlier on a catch by rookie tight end Eric Ebron but the play was reversed after a replay review determined he dropped the ball.

The Lions doubled their lead to 14-0 early in the second when Mathis stepped in front of Watkins, intercepted Orton’s short throw and raced 41 yards untouched into the end zone.

Carpenter’s 45-yard field goal got the Bills on the board with 6:43 remaining in the half.

Recently-signed Henery missed two field goals in the third quarter and Carpenter also had one bounce off the uprights. Carpenter connected on his next try, a 25-yarder, late in the third to make it 14-6.

Buffalo tied it with 9:25 remaining on a 10-play, 74-yard drive, highlighted by Orton’s 42-yard pass to wide receiver Marquise Goodwin. Orton found backup tight end Chris Gregg open in the end zone for a two-yard touchdown and running back Fred Jackson ran for the 2-point conversion.

NOTES: Bills CB Ron Brooks suffered a neck injury when he was upended while covering a punt midway through the first quarter. He left the field on a stretcher and was transported to a nearby hospital for further evaluation. … Buffalo played without Pro Bowl DT Kyle Williams (knee). Detroit was depleted on offense with the absences of RBs Joique Bell (concussion) and Theo Riddick (hamstring) along with TE Joseph Fauria (ankle). … Detroit CB Rashean Mathis’ defensive score was the fourth touchdown of his career but first since 2008, when he played for Jacksonville. … Bills QB Kyle Orton is 5-0 against the Lions. He won all of his previous four starts against Detroit when he played for Chicago. … Buffalo defensive coordinator Jim Schwartz had a 29-51 record as Detroit’s head coach the past five seasons. … The series was tied at 4-4-1 and the teams hadn’t met in the regular season since the Bills’ 14-12 victory on Nov. 14, 2010.