Buffalo Bills (8-6) at Oakland Raiders (2-12)

Sunday, 4:25 p.m. ET, at o.Co Coliseum, Oakland, Calif. – TV: CBS

*TV announcers: Brian Anderson, Chris Simms

*Keys to the game: The Raiders gave up 216 yards on their six plays of 20-plus yards allowed last week against the Chiefs, and the conservative Bills will loosen the reins on QB Kyle Orton in hopes of striking a big gain or two. That puts an arrow over the head of CB DJ Hayden, who might have whiplash after last week’s rough outing at Kansas City. He’ll defend WR Sammy Watkins, the No. 4 overall pick last spring, who has suffered his own bouts of inconsistency.

The Bills still prefer to squeeze the ball on offense, spinning through running backs to keep the chains moving and letting their defense do the dirty work.

Buffalo leads the league in sacks and three players on the line have at least nine sacks. That’s a tough menu to read for rookie QB Derek Carr, but he has done well to get the ball out quickly, taking just 20 sacks in 529 drop-backs.

*Matchup to watch – Raiders OLB Khalil Mack vs. Bills LT Cordy Glenn: The massive Glenn draws University of Buffalo product Khalil Mack, who continues to stand out on a bad defense. Mack can pressure inside and out, and Glenn might need help to keep him at bay.

*Player spotlight – Bills RB C.J. Spiller — Spiller has missed the last seven-plus games with a broken collarbone, but he may be back in the lineup against Oakland on a limited basis. The Bills could use his big-play speed.

*Fast facts: Orton needs three TD passes to reach 100 for his career. … Oakland is minus-16 in turnover margin.

WHO WILL WIN AND WHY

The Bills fell behind 21-3 – but rallied to win – in their last meeting with the Raiders. The Raiders won’t go quietly trying to make a positive statement on behalf of 2-8 interim coach Tony Sparano, but Oakland is turned back by a rugged defense on top of its game.

*Our pick: Bills 26-16