San Francisco 49ers (7-5) at Oakland Raiders (1-11)

Sunday, 4:25 p.m. ET, at o.Co Coliseum, Oakland – TV: FOX

*TV announcers: Chris Myers, Ronde Barber, Jennifer Hale

*Keys to the game: After watching QB Colin Kaepernick struggle with his accuracy in last week’s loss to Seattle, look for the 49ers to come out trying to establish RB Frank Gore against the league’s 27th-ranked run defense. The only thing that can really trip San Francisco up Sunday is multiple turnovers, and the Raiders do sport a solid secondary on the strength of a pass rush that can get home.

Offensive coordinator Greg Roman has come under intense fire in the Bay Area, and the 49ers need to get back to allowing Kaepernick to use his dynamic dual-threat skillset rather than trying to develop him into a pocket passer.

The Raiders’ margin for error is minute, and things can quickly snowball when they fall behind early as they did in last week’s 52-0 washout in St. Louis. The 49ers allow only 4.1 yards per carry, but the Raiders must stay committed to the ground game for as long as they can with rookie QB Derek Carr coming off a very rough outing against the Rams. San Francisco has 16 interceptions and if Oakland falls behind early, the 49ers will quickly add to that total.

The problem for the Raiders is they’re not capable of sustaining many drives, and San Francisco holds opponents to an average starting field position of the 23.9 yard line.

*Matchup to watch – 49ers OLB Ahmad Brooks and Aaron Lynch vs. Raiders RT Menelik Watson: Brooks isn’t happy about losing snaps to the rookie, but both possess the quickness and strength to get by the best right tackles in the league. The 25-year-old Watson has great physical skills, but has yet to put it all together and has been highly inconsistent.

*Player spotlight – Raiders CB DJ Hayden: Finally healthy, the second-year player has flashed playmaking skills. The Raiders must get turnovers, and Kaepernick threw two picks to that side of the field last week – granted, they went to All-Pro Richard Sherman.

*Fast facts: The 49ers have played Thursday night games in four straight seasons. They have won their games following the previous three Thursday night contests by a combined score of 84-6. … Carr has a 52.2 passer rating in the fourth quarter when the game is within seven points.

WHO WILL WIN AND WHY

The 49ers are desperate and well rested. The Raiders should at least be motivated against their cross-Bay rivals, but the talent level isn’t there to compete for four quarters.

*Our pick: 49ers 27-6