PITTSBURGH — Ben Roethlisberger won his 100th career game in grand fashion, setting team records with 522 passing yards and six touchdown tosses to guide the Pittsburgh Steelers to a 51-34 win over the Indianapolis Colts at Heinz Field on Sunday.

Roethlisberger completed a career-best 40 of 49 passes and his 522 passing yards was the fourth-highest total in NFL history. Andrew Luck of the Colts had 400 yards passing and three touchdowns.

Indianapolis, coming off of a shutout of the Cincinnati Bengals last week, made it a one-possession game, 42-34, with a pair of touchdowns 57 seconds apart to end the third quarter but the Steelers kept the accelerator to the floor.

The 51 points were the most scored by the Steelers (5-3) during coach Mike Tomlin’s eight seasons as coach. The AFC South-leading Colts (5-3) had their five-game winning streak snapped. The teams combined for 85 points, most in the NFL this season.

Roethlisberger, the first player in NFL history with multiple 500-yard passing games, had a 150.6 passer rating for the Steelers, who wore their black and gold bumblebee throwback jerseys.

He tossed a pair of touchdown passes to rookie Martavis Bryant, covering 2 and 5 yards, and another pair of 47 and 8 yards to Antonio Brown, who led the team with 10 receptions for 133 yards.

Roethlisberger’s other TD passes were an 18-yarder to Markus Wheaton and an 11-yarder to tight end Heath Miller, who had more than 100 yards receiving Sunday and also in Roethlisberger’s 503-yard passing effort at Green Bay on Dec. 20, 2009.

Roethlisberger completed 23 of 27 passes for 320 yards and four touchdowns before halftime as the Steelers rallied from an early 3-0 deficit to take a 35-20 halftime lead.

Wheaton’s touchdown catch was the first of his career. Bryant, a rookie, has three TD catches in the past two games after being inactive the first six. Brown pushed his total to a team-leading seven TD with another 100-yard receiving game.

Pittsburgh cornerback William Gay stepped in front of a Luck pass intended for Colts wide receiver Hakeem Nicks and returned the interception 33 yards for a touchdown in the first half.

Luck, who went over 300 yards for the sixth consecutive game, completed 26 of 45 passes but was intercepted twice and sacked twice.

With the Colts within a possession after recovering a fumble, Luck surrendered a safety to the Steelers with an intentional grounding call in the end zone in the fourth quarter.

Luck had TD passes of 31 yards to wide receiver Donte Moncrief, 28 yards T.Y. Hilton and 21 yards to tight end Dwayne Allen.

Ahmad Bradshaw scored on a 12-yard run for the Colts and Adam Vinatieri also kicked field goals of 31 and 23 yards.

NOTES: QB Ben Roethlisberger passed for more than 300 yards in the first half for the first time in his career. He also had a pooch punt blocked. … Roethlisberger became the first quarterback in NFL history with two 500-yard games. The top single-game totals were recorded by Norm Van Brocklin (Rams), 554, vs. New York Yanks, 1951; Warren Moon (Oilers), 527, vs. Chiefs, 1990; Matt Schaub (Texans), 527, vs. Jaguars, 2012; Boomer Esiason (Cardinals), 522, vs. Redskins, 1996; and Roethlisberger on Sunday. … Steelers ILB Ryan Shazier (sprained knee) returned after a four-game absence and got the start. … WR Hakeem Nicks started in place of injured Colts WR Reggie Wayne (elbow), who did not dress. … Steelers RB Le’Veon Bell injured his right ankle in the second quarter, but he returned. … Colts CB Vontae Davis injured his knee in the first quarter and did not return. … Colts OLB Erik Walden suffered a hip injury and did not return. … Pittsburgh will welcome the Baltimore Ravens next Sunday, while Indianapolis plays the New York Giants on Monday (Nov. 3).