ORCHARD PARK, N.Y. — Quarterback Kyle Orton threw a 2-yard touchdown pass to Sammy Watkins with one second left in the game to lead the Buffalo Bills to a 17-16 comeback victory over the Minnesota Vikings on Sunday at Ralph Wilson Stadium.

Orton completed passes on fourth-and-20, third-and-12 and second-and-20 on the 15-play, 80-yard winning driving for Buffalo (4-3).

Orton was 30-of-42 passing for 282 yards and two touchdowns. He threw one interception and lost a fumble. Watkins caught nine passes for 122 yards and both touchdowns.

Buffalo won despite turning the ball over four times.

Defensive end Everson Griffen had a career-high four sacks and a forced fumble, rookie linebacker Anthony Barr recovered two fumbles and safety Robert Blanton had an interception and a fumble recovery for Minnesota (2-5).

Rookie running back Jerick McKinnon rushed for 103 yards against the Bills’ top-ranked rushing defense and rookie quarterback Teddy Bridgewater was 15-of-26 passing for 157 yards, one touchdown and two interceptions.

Blair Walsh’s 33-yard field goal made it 16-10 with 11:45 left in the fourth quarter. The Vikings’ 12-play, 36-yard drive spanned 5:43 and was the longest series of the game.

Walsh kicked a 55-yard field goal to give Minnesota a 13-10 lead just before halftime. Blanton intercepted Orton at the Vikings 40 with 1:24 left in the half.

Buffalo’s top two running backs were carted off the field in the first half. Fred Jackson injured his groin on the final play of the first quarter and C.J. Spiller injured his left collarbone at the end of a 53-yard run in the second quarter.

Spiller’s long gain on his only carry of the game set up Dan Carpenter’s 31-yard field goal that tied the game 10-10 with 4:05 left in the first half.

Wide receiver Cordarrelle Patterson scored a 4-yard touchdown on a screen pass from Teddy Bridgewater to give the Vikings a 10-7 lead at 6:17 of the second quarter. A 38-yard pass to wide receiver Greg Jennings put the Vikings in scoring range.

Orton threw a 26-yard touchdown pass to Watkins one play after cornerback Leodis McKelvin made his second interception of game to put the Bills ahead 7-3 at 9:23 of the second quarter.

Walsh made a 40-yard field goal to give the Vikings a 3-0 lead late in the first quarter. Minnesota started its drive at the Buffalo 27 after safety Harrison Smith forced a fumble by Bills wide receiver Robert Woods that was recovered by linebacker Anthony Barr. It was Buffalo’s second lost fumble by a wide receiver in the first quarter.

NOTES: Vikings LB Chad Greenway returned to the lineup after missing three games with broken ribs. Greenway forced a fumble in the first quarter. … The Bills had three first half turnovers for the second straight game. … McKelvin has four interceptions on the season, a career high. … The Bills inducted broadcaster Van Miller onto the Wall of Fame at Ralph Wilson Stadium during a halftime ceremony. Miller, the Bills’ radio play-by-play announcer from 1960-70 and 1978-2003, was driven out to the midfield in a 1976 Cadillac El Dorado.