New England Patriots (3-2) at Buffalo Bills (3-2)

Sunday, 1:00 p.m. ET, at Ralph Wilson Stadium, Orchard Park, N.Y. – TV: CBS

*TV announcers: Kenny Albert, Daryl Johnston, Tony Siragusa

*Keys to the game: The Patriots’ offensive resurgence in their Week 5 blowout of previously-undefeated Cincinnati was fueled by the ground game churning out 220 yards on 46 attempts. It’s clear that New England’s offensive line is far more productive run-blocking, and with RBs Stevan Ridley and Shane Vereen setting the table QB Tom Brady isn’t so vulnerable in a pocket that tends to collapse quickly. But repeating that formula against Buffalo’s second-ranked run defense will be a tall task.

Bills QB Kyle Orton is tasked with managing the game and avoiding turnovers. He was able to rally Buffalo last week despite throwing a pick-six. Orton doesn’t often stretch the field beyond 10 yards, but he’ll have to take a few shots to WR Sammy Watkins to keep New England’s safeties honest. Buffalo is averaging 4.0 yards per carry and the offense is most efficient when RBs C.J. Spiller and Fred Jackson are getting regular touches and creating manageable third downs.

*Matchup to watch – Patriots RG Ryan Wendell vs. Bills DT Kyle Williams: Williams hopes to return after missing last week’s game due to a knee injury, but Stefan Charles helped limit Detroit to 69 rushing yards in his place. Wendell is the Patriots’ former center who helped solidify the line play when re-inserted into the starting lineup at right guard against the Bengals.

*Player spotlight – Patriots DT Casey Walker: Signed off Carolina’s practice squad, Walker made his Patriots debut against the Bengals and played 14 snaps. Coach Bill Belichick hopes the youngster can continue to improve and play an increased role as a run-stuffer.

*Fast facts: The Patriots are 23-5 against the Bills under coach Bill Belichick, and have won 20 of the past 21 meetings. … Orton is one of five NFL quarterbacks since 1960 to throw for 300-plus yards in a game for five different teams.

WHO WILL WIN AND WHY

The Patriots played with a considerable collective chip on their shoulder last week, and still have plenty of doubters to disprove. In a lackluster field position game, the Patriots take the blue-collar approach to yet another win over the Bills.

*Our pick: Patriots 23-21