Philadelphia Eagles (3-0) at San Francisco 49ers (1-2)

Sunday, 4:25 p.m. ET, at Levi’s Stadium, Santa Clara, Calif. — TV: FOX

*TV announcers: Joe Buck, Troy Aikman, Erin Andrews

*Keys to the game: The Eagles are the first team in history to rally from double-digit deficits in each of the first three games of the season. Why Philadelphia has been outscored 34-6 in the first half is up for debate, but coach Chip Kelly does need to get RB LeSean McCoy (2.9 yards per carry) untracked to keep QB Nick Foles from absorbing constant punishment. The concern is a depleted offensive line turning to its backup center and third-string left guard.

The debate in San Francisco centers on the increasing use of four- and five-receiver formations on offense. RB Frank Gore is not happy about his declining workload, while coach Jim Harbaugh steadfastly defends taking advantage of the team’s personnel. The 49ers have been the polar opposite of the Eagles, outscoring opponents 59-16 in the first half this season, but crumbling in the second half each of the past two weeks. With TE Vernon Davis expected to return this week, expect the 49ers to feature more three-wideout formations and attack the vulnerable Eagles secondary.

*Matchup to watch — Eagles LG Matt Tobin vs. 49ers DL Justin Smith: Making his first career start with David Molk sliding over to fill in for C Jason Kelce (sports hernia), Tobin goes up against one of the best 3-4 defensive linemen in the game. Smith has cupboard full of moves, and the 49ers will also run stunts to test Tobin against faster pass rushers.

*Player spotlight — 49ers S Jimmie Ward: The rookie has been charged with getting beat for four touchdowns while struggling to cover slot receivers the past two weeks. He’ll need to tighten his coverage against WR Jordan Matthews, a fellow rookie coming off a two-touchdown game.

*Fast facts: Foles has a 129.2 passer rating with 22 touchdowns against just two interceptions in his past eight road games. … The 49ers are 14-1 when Colin Kaepernick has a passer rating of at least 100.

WHO WILL WIN AND WHY

The Eagles’ inability to stop the run consistently sets up too many short-yardage situations for opponents. That’s where 49ers QB Colin Kaepernick’s versatility becomes a back-breaker.

*Our pick: 49ers 34-27