NASHVILLE — The Tennessee Titans head to Indianapolis this week in a familiar spot.

They have a losing record, an injured quarterback and a team that looks outmanned in facing the division favorite Colts.

That’s nothing new for the Titans, who have lost 10 of the past 11 meetings with the Colts, with their last victory coming in 2011 — a year Indy won just two games, with one of those wins coming at the Titans’ expense.

The worst part about it, however, is that quarterback Jake Locker’s situation is uncertain after he suffered a sprained wrist in Sunday’s 33-7 loss to the Cincinnati Bengals last week.

Locker did not practice on Wednesday, and his right hand was visibly swollen as he was using his left hand even to hold a bottle of water on the practice field. Not being able to play this week could be a setback for Locker, who has missed 14 games with injuries the past two seasons and is in the final year of his rookie contract this year after the Titans declined a $14 million option.

“I’m getting better each day,” Locker said. “It was something I felt a little bit during the game, and then when the adrenaline stopped, it started hurting a little more. I’m just working as hard as I can to get back as soon as possible.”

Coach Ken Whisenhunt was intentionally vague in talking about his starting quarterback, who is coming off two straight inconsistent performances after a strong start in Week 1.

“He didn’t do much, but he was mentally into it,” Whisenhunt said. “I can only go on what the trainer and what he tells me. We’ve talked, and knew it was gonna be a process. Nothing’s changed about that. He’s getting better. It’s just a question of how quickly he progresses.”

Backup Charlie Whitehurst, who has been the very definition of a backup for most of his career, got the practice reps on Wednesday in what could be his first meaningful action in three years. He has not thrown a pass in a game since 2011.

“We’ll see what happens. I’m preparing like I’m going to start, like I do this week. I was getting more reps. We’re day by day and I’m ready if called upon,” Whitehurst said. “I think I’ve got a better chance to start this week than I do normal weeks.”